Amino Acids & Peptide Building Blocks

Welcome to OUHE Technology’s catalog of amino acids and peptide building blocks. We supply high-purity L- and D-enantiomers, non-proteinogenic amino acids, and N-protected derivatives essential for solid-phase peptide synthesis (SPPS), chiral pool synthesis, and peptidomimetics. Use our advanced search bar to filter by CAS number or product name to secure your target building blocks.

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Preserving Enantiomeric Purity and Zwitterionic Stability

Due to their zwitterionic nature, free amino acids exhibit high melting points and poor organic solubility. Preserving absolute stereochemical integrity is critical in peptide chemistry. At OUHE Technology, we guarantee high enantiomeric excess (% ee) for our L- and D-amino acids. We pack our hygroscopic derivatives under dry nitrogen to prevent moisture-induced clumping and preserve chiral building block stability.

Structural Classes: From Standard Enantiomers to Chiral Pool Synthons

  • L- & D-Proteinogenic Amino Acids: Premium chiral pool starting materials and building blocks for pharmaceutical APIs and clinical nutrition.

  • Non-Proteinogenic & Beta-Amino Acids: Non-standard amino acids (including cyclic and homo-derivatives) optimized for constructing peptidomimetics with improved metabolic stability.

  • N-Protected Amino Acids (Fmoc, Boc, Cbz): Essential monomers pre-configured for solid-phase peptide synthesis (SPPS) and solution-phase peptide coupling.

 

Chiral HPLC % ee Verification and Custom Protecting Group Strategies

Synthesizing peptides requires highly selective protection of the amine, carboxyl, and side-chain functional groups. We offer professional custom protecting group modifications (including Fmoc, Boc, Cbz, t-butyl, and benzyl esters) tailored to your synthetic routes. We verify optical and chemical purity using high-resolution chiral HPLC and NMR spectroscopy, ensuring absolute stereochemical precision before scaling from milligrams to kilograms.

Frequently Asked Questions

A: We measure chiral purity and enantiomeric excess (% ee) using high-resolution chiral HPLC with polysaccharide-based stationary phases. We also provide optical rotation (α -D) measurements and NMR spectra to confirm absolute stereochemical configuration.

A: We provide a comprehensive range of pre-protected amino acids, including N-Fmoc, N-Boc, and N-Cbz derivatives, alongside orthogonal side-chain protections (such as Trt, tBu, and Pbf) to ensure seamless coupling and deprotection cycles.

A: Yes. We specialize in the custom synthesis of unnatural and beta-amino acids using chiral pool starting materials or asymmetric synthesis. We scale production from milligrams up to multi-kilogram pilot batches under strict quality control.