Acyl Chlorides & Sulfonyl Chlorides
Welcome to OUHE Technology’s catalog of acyl chlorides and sulfonyl chlorides. We supply high-purity aliphatic acyl chlorides, aromatic sulfonyl chlorides, and sulfonyl halides essential for Friedel-Crafts acylations, sulfonamide synthesis, and alcohol activation. Use our advanced search bar to filter by CAS number or product name to secure your moisture-sensitive intermediates.
Inhibiting Violent Hydrolysis and Corrosive HCl Gas Release
Acyl and sulfonyl chlorides are highly electrophilic and react violently with trace moisture, hydrolyzing back into their parent acids while releasing corrosive, choking hydrochloric acid (HCl) gas. At OUHE Technology, we prevent this moisture-induced hydrolysis and HCl release by packaging our reactive halides under high-purity dry nitrogen in specialized, chemically resistant amber glass or fluorinated containers.
Dual Synthetic Utilities: From Sulfonamides to Alcohol Activation
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Aromatic & Aliphatic Acyl Chlorides: Powerful electrophiles optimized for Friedel-Crafts acylations and rapid amide/ester couplings with amine or alcohol partners.
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Sulfonylation Reagents (such as TsCl & MsCl): Key sulfonyl halides utilized for activating poorly leaving hydroxyl groups into excellent tosylate (OTs) or mesylate (OMs) leaving groups.
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Sulfonyl Chlorides for APIs: Structural precursors engineered for synthesizing sulfonamide pharmacophores, a vital motif in antibacterial and diuretic medications.
Strict Moisture Control and Chromatographic Purity Verification
Because acyl and sulfonyl chlorides can degrade into sulfonic or carboxylic acids during storage, verifying active halide titer is a major quality concern. We utilize high-resolution capillary GC or HPLC to accurately measure active compound purity and monitor free acid content. We also perform Karl Fischer titration to strictly control water content (<0.05%), ensuring reliable stoichiometric control.
Frequently Asked Questions
A: Acyl chlorides react instantly with atmospheric humidity, hydrolyzing and releasing corrosive hydrochloric acid (HCl) gas (which appears as a white mist). We package our moisture-sensitive chlorides under dry nitrogen to prevent this.
A: We measure active halide purity and detect free acid degradation products using high-resolution HPLC or capillary GC with moisture-free preparation. We also perform Karl Fischer titration to ensure water content is kept below 0.05%.
A: Yes. Our high-purity sulfonyl chloride reagents (typically ≥98% or ≥99%) are dry and ready to use, serving as excellent agents to convert alcohols into tosylate or mesylate leaving groups in the presence of an organic base.